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1.
shortened from Treforest.
little village in south wales playing host to the university of glamorgan
hey, when you back in tref?
by hanahhavok August 23, 2004
 
2.
The condition of having multiple serious psychological disorders. (EX- Paranoid schizophrenia, multiple personality disorder, anti-social disorder) People with this condition often times are unable to function properly in society or hold normal conversations with people.
He is so Tref that he needs to go to the hospital and be checked out
by 102SPT November 19, 2006