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1. tough shit
too bad.
Person 1: Damit, I failed this test, my parents will beat me

Person 2: Tough shit
by DeathBunny Apr 5, 2004 add a video
2. tough shit
harsh way of saying too bad
A: Mrs. Smith I forgot what the homework was.

B: Tough shit, pal!
3. tough shit
a way to describe an incident or occurence in life as troublesome, or in many cases, to express a generally fucked up state of living.

imagine the literal "tough shit", it's like a real burning case of the squirts, only as a metaphor for life. most commonly emphasized sarcastically, as to mock the seriousness of the situation.
Bob: I haven't slept in days, there's a terrible rash on my crotch, my car got impounded, some other guy is fucking my girlfriend, and I just lost my job.

Jane: Tough shit man.
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