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1.
basically, when some one dies
he went toes up
by hiphophead293847 August 14, 2009
 
2.
To pass out from heavily drinking, it can also mean sleeping in general but usually refered to when passing out while drinking. (You're toe's are facing up when you pass out on your back is the origin)
Mario got so drunk that he was toe's up by midnight.
by Mike Ondrunko August 23, 2003