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4.
someone with a huge ass.
"Look at the big A over there!"
"Yeah, I'd tap that."
by wilfs January 06, 2008
 
1.
slang for the city of Anaheim, California which is located in Orange County near LA. the name is derived from the giant letter A outside of Anaheim stadium which can be seen from the 57 freeway.

A-town is a word commonly mistaken for the city of Anaheim which in reality refers to Atlanta, Georgia.
I'm representin from the Big A.
by xxWhE3L5xx November 11, 2007
 
2.
Anal sex. Particularly gay male anal sex. From the film Reality Bites (1994)
Sammy Gray/SteveZahn: "I think the real reason that I've been celibate for so long isn't really because I'm that terrified of the big A, it's because I can't really start my life without being honest about who I am."
by NinetiesNiles February 27, 2013
 
3.
If you are sick and you come to work and complain about being sick, then everyone can make fun of you for having "The Big A".. i.e. AIDS.

Note: You may not actually want to use this word if you suspect someone actually has AIDS.
Dan comes to work with a cold. His eyes are watering and her nose is running. Coworkers mock him mercilessly for having "The Big A."
by Kate12345 October 01, 2007