The medical condition known by doctors as diarrhea which comes as a direct result of a late-night McRun.
Max: Holy shit Tim! We shouldn't have gone on that McRun last night!

Tim: What's the matter?

Max: That McRun gave me a NASTY case of the McRuns!!
by Maxwell Dope November 9, 2013
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The shameful and disappointing trip a person must take to a shitty fast food restaurant in the middle of the night when there are no better options available.
Max: "Hey, Tim. I'm starving. Let's go eat."
Tim: "Nah man. Nothing's open."
Max: "McRun?"
Tim: "Down."
by Maxwell Dope November 8, 2013
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The act of running to the nearest toilet before expelling your bowels in your pants in public after ingesting McDonald's 15 mins prior.
John: Oh boy, stomach cramps it's happening!!
Alex: The McRun!! Run man, run! You have less than 15!
John: Help me God!!!!
Alex: God bless that man, for the unspeakable horrors that come after.
by boom&bewm October 21, 2014
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