Top Definition
What you say when referencing a slut or a girl that messes with you. Often when a girl like that walks by and one of your homies starts sizing her up and talking about her, you hold him back and warn him "yo, that girl is poison." She will enter your bloodstream and kill you within weeks.
Bell Biv Devoe said it best and said it first. Never trust a big butt and a smile, because that girl is poison.
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