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1.
to interfere with, to meddle
It's important not to tamper with unknown chemicals in a science lab.
by Rocking4god April 12, 2007
 
2.
to fondle with a member of the fairer sex, to touch her tits or fanny
I ulled a slut last night I didnt shag her just let her tamper with my cock
by Pablo Escobar January 11, 2004