Top Definition
An extremely irritating blonde chick that has a nasty habit of ruining parties and various other social gatherings purely by showing up and acting stupid. Talky McBuzzkill can be easily identified by her unusually high-pitched voice and unintelligent style of thinking. Also, things are constantly coming in and out of her mouth.
Person 1: Hey, did you hear Sarah's coming to the party tonight?

Person 2: Oh no, not Talky McBuzzkill! She ruins all the fun.

Person 1: Yeah man, did you hear about happened at Springfield Mall?
by asdfghj; February 26, 2008

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