Top Definition
To follow in example of Nikki Sixx, "Sixx'n" refers to overdosing, being revived in an ambulance, escaping the hospital, and going home only to overdose again. When used as a verb in casual conversation, "Syxx'n" does not necessarily have to refer to heroine use, but can describe being under the influence of any substance, and getting into trouble.
Dude, I'm totally syxx'n it up this weekend.
by Sic6Sixx August 11, 2011

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