The phrase can be used as part of a sentence, or as a comment on its own.
Tim (jokingly): You probably have Swine Flu.
Jim: Swine Flu!!!!
Tommy: Quick, call the hospital and the local news crew!
Yea it was weak though, it had the swine flu so it was over hella early.
el guapo: 'wait muchacho, she gots tha swine flu man'
el nombre: 'i'ma fuck that pig'