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Something that sets you back. It keeps you from doing something and can cause great inconvenience to someones life. A setback may just knock you off your time schedule or it could be stopping you from doing something you drastically need to do. Setbacks are not good, most of the time...
"I really must get my sculpture finished today, but I don't have enough resources to finishes it. That means I'm gonna have to go out and buy some then I'll be off my time schedule. Dang!"

(^^^Not having enough resources to finish his/her sculpture was this persons setback)
Setback by SPECCYKID123 April 19, 2011
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Setback Syndrome 

When a human being purposely or accidentally wastes the times of other human beings
Short: yo I'm going to get fined 10,000$ for parking can you move my car
Big : shutup
By-Law: ticket for 10,000 for parking in government property
Short : Thanks bro...you and your setback syndrome
Big : (hahaha) I love you broo
Setback Syndrome by Zingy666 January 2, 2013

sweetback 

70's black slang for a large penis.
Don't slip that girl your sweetback, she's got the clap!
sweetback by Dave December 28, 2005

Sweetback 

Sweetback: The true definition of a sweetback is a male gold digger,a kept man as mentioned in the book Invisible man by Ralph Ellison.
Guy is a sweetback. Lady pays the rent but his only love is cold hard cash.
Sweetback by well-read June 3, 2022

sweetback 

sweetback refers to a dude who is too smooth and fresh to go by any other, less respectful, term.
Shit, sweetback, you be smoove with the bitches!
sweetback by Marco St. John June 22, 2004
(n.)- A racist, derrogatory, offensive term used to describe of person of Mexican or El Salvadorian descent. Sweat meaning getting there back wet and sweaty working in the fields, coining the term "sweatback."
Dylan tried to shank us when we called him a sweatback.
sweatback by Maximus Bluntoff April 25, 2006

Bill's Sweatback 

Bill Marty Mart's small, yet meager, former vehicle that lacked proper air conditioning abilities. It was inevitable to experience a sweatback when riding in it.
Bill drinks a gallon of gatorade and takes off his shirt prior to driving home in Bill's sweatback.
Bill's Sweatback by Klottski December 24, 2008