A girl that would otherwise be hot except for some issue such as having some back fat or bad skin. The issue is not enough that you would not enjoy boning her, but it is just enough so that she has an inferiority complex so that she would actually bone you.

a spot on the body that responds pleasurably to a to a touch or caress

On the male anatomy, the most sensitive spot on the penis (the underside where the head and the shaft meet). In uncircumcised men, this area is often referred to as the frenum or frenulum.

the place in a room where one can experience optimal enjoyment of the speaker configuration.

The patch of skin between the asshole and the balls; also known as the chode or gooch.

a woman's clitorus

Or

a male's prostate gland, in which being probed in gay sex through the anus forces the guy to ejaculate without touching his dick, like in the movie "Road Trip"

the one spot on a surfboard on which the surfer has centered between his/her legs for the best control and manipulation. usually this spot is found by holding one side of the surfboard rail out in one hand and trying to find it's center of balance.

A spot on the human body that, if pierced, will kill a man within a few seconds, if not instantly. An example would be the abdominal aorta, located to the left of the spine, fourth lumbar down. Bleed to death in under ten seconds if stabbed there. Another would be at the base of the skull, top of the spinal column.