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1.
To run/jog or engage in cardiovascular activity, most often after a night of drinking, in order to rid the body of the toxins associated with said heavy drinking.
- "Hey, man, wanna go get some brunch?"

- "Naw, bro, I gotta go sweat out toxins, or "s.o.t". I won't be done jogging until 2:00."
by Jeff Howard June 05, 2007
 
2.
To run/jog or engage in cardiovascular activity, most often after a night of drinking, in order to rid the body of the toxins associated with said heavy drinking.
- "Hey, man, wanna go get some brunch?"

- "Naw, bro, I gotta go sweat out toxins, or "s.o.t". I won't be done jogging until 2:00."
by Jeff Howard June 05, 2007