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57.
it means shut the fuck up used online when you want someone to stop talking
Dude STFU right now
by pyrokilla February 27, 2008
 
58.
Shut, The, Fuck, Up, Son
oli: blah blah blah
Jimmy: STFUS!
by jimmy perry May 03, 2010
 
59.
The opposite of SNAFU. Situation Terrific Feelin' Upbeat! First used by mid-western housewives at social gatherings such as picnics, little-league games and bingo night. The term is gradually spreading across the US and makes for confusing if not interesting web chat.
LUANN: How's the bake sale goin' Judy?
JUDY: STFU Luann! We've already met our sales goal, have run out of gingersnaps, and are about to sell our last box of cupcakes!
by superdoodie May 06, 2009
 
60.
an irrational response to your mother's comments that make more sense than your brain can accommodate
comfortably
"I thought we were going to spend the day together for Father's Day"
"Your Dad has been here all day, he worked in the yard for hours and just went to hit golf balls with your brother, they will be back by six"
"Oh, so I have been here all day, but he can go off with my brother" some more words of unkindness and then:
stfu, i am leaving
ridiculous.
by zzellda June 15, 2008
 
61.
Shut The Fuck UP

or if u want there is

Shut The Fuck Up You Bitch: stfuyb
and
Shut Your Fuckin' Mouth: syfm
Nicole and Josh are not real ppl in this thang

Nicole: UR GAY!!!!! STFU!!!!!!!!
Josh: Na, im just fukin wit ya

by 12091983 December 20, 2007
 
62.
be quiet already (from shut the fuck up)
A: Read the article. It's no joke.

B: STFU you liar.
by The Return of Light Joker July 19, 2009
 
63.
the acronym of what you say to someone who spells this out in a real life conversation and other overused acronyms like wtf rather than saying the real thing
fag: stfu (spells out stfu) I only kiss that other guy cause uh..it's my religion so wtf (spells out wtf) you talking about I'm not gay.

me: No YOU shut the fuck up you don't even know proper english AND you kissed a guy, fag.
by nub_sauce February 23, 2007