stewie has been described as (to some degree) a caricature of Sir Rex Harrison. his affected english accent and effeminite vibe also draw comparisons to actor David Hyde Pierce.
Stewie has an evil personality which is said to have been induced by his mother Lois smoking Marijuana while she was pregnant with him. His scary almost British accent is known as an evil Rex Harrison.
He is intent on world domination and the extermination of his mother, but also plans to kill many other people once he rules the world.
(knocks the broccoli off the fork and across the table)
Stewie Griffin: Damn you! Damn the broccoli! and damn the Wright brothers!!!
He also likes to be called Snake Griffin.
" Stewie Griffin, did you unhook mommy's bra? "