Top Definition
1. Latin for "the Holy Spirit/Ghost" (one of the three "facets" of God in Christianity)

2. The last words of the family prayer in the movie "The Boondock Saints."
"In nomine Patris et Filii, Spiritus Sancti."
(In the name of the Father, the Son, and the Holy Spirit/Ghost.)
by Jess Willis June 17, 2006

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