To get ready by consuming a drug
"Lets spike up before we go to the concert"
by 420666 September 29, 2007
To challenge another track team member to a race to prove who is faster.
James: All you freshman are soo slow.
Q: James, why you talk all this trash, you know i can smoke you in a race.
James: Alright then , Spike Up Baby and lets go.
by Ek, the Decath November 26, 2009

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