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1.
knowing something special, exciting or dangerous will happen soon
with will's spider sense he was able to avoid the gang bang that happend down the alley he decided not to walk down.
by bob dylan October 09, 2003
 
2.
Strong intuition. A gut feeling.
"My spider sense is tingling - those two men, it's because of them!" - Spider Man, Marvel Comics, 1963
by leica0000 October 07, 2011