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1.
To just straight up trip and go crazy, usually when you are mad
Ay, dog, that nigga's straight spazzin, man
by Maurice July 02, 2003
 
2.
The most exciting form of expression, similar to "Bitchin' Awesome", "Steak Sauce", or "Wicked"

According to Ryan, this word is quite popular in the future.
Golly gee, Camp was Spazzin!
by Captain Lutherzord July 27, 2008