A large black woman with an attitude and a deep singing voice. EX: Aretha Franklin, Whoopi Goldberg
Latrell: "I hear you been poppin' LaKeisha lately. Got yo' self a soul sista I see."
Donell: "Hell naw nigga, that ho can't sing. She ain't nothin' but a BIG BITCH."
by Nick D February 09, 2004
Your number one girlfriend, typically used if you are a girl.
Liliana: Did you hear about Dana? Good gossip!
Claudia: WHAT! Dana's my numba one soul sista!
by S1m0n3 November 09, 2007

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