Top definition
When a certain set of circumstances bogs you down and makes you depressed or leaves you wanting to give up. A feeling of immense hopelessness or depression.
This town is starting to give me soul cancer.
by Seb A. November 04, 2007
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2
When something makes you cringe so bad it gives you stage 4 soul cancer.
"Your post gave me soul cancer"
or
"Your post gave me stage 4 soul cancer"
by User666999 February 16, 2017
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