Describes a person using Viagra recreationally. The "smurf" relates to the pill being the same blue colour as a smurf. "my ride" related to the upgraded performance as in "pimp my ride"
Jason: I'm in for a big night tonight. I've got the little blue pills so I know it's gonna be good!
Junior: Cool Jas, do you have a spare to share? I wanna smurf my ride too!!!