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1.
An acute, highly infectious, often fatal disease caused by a poxvirus and characterized by high fever and aches with subsequent widespread eruption of pimples that blister, produce pus, and form pockmarks. Also called variola.

After 9/11, there was concerns terrorists might use smallpox in an attack.

Supposedly the US holds enough vaccine for it's entire population in case there were ever an outbreak.
Don't get smallpox, or else you are screwed.
by History Channel November 27, 2005
 
2.
1. The sexually transmitted disease you get from having unprotected sex with a midget. 2. The sexually transmitted disease you get from having unprotected sex with a guy with a small penis.
1. She had a bad case of smallpox after she did the short, short man. 2. She had a bad case of smallpox after she did the short, short man.
by chickiechickie September 13, 2007