Top Definition
An acute, highly infectious, often fatal disease caused by a poxvirus and characterized by high fever and aches with subsequent widespread eruption of pimples that blister, produce pus, and form pockmarks. Also called variola.

After 9/11, there was concerns terrorists might use smallpox in an attack.

Supposedly the US holds enough vaccine for it's entire population in case there were ever an outbreak.
Don't get smallpox, or else you are screwed.
by History Channel November 27, 2005

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1. The sexually transmitted disease you get from having unprotected sex with a midget. 2. The sexually transmitted disease you get from having unprotected sex with a guy with a small penis.
1. She had a bad case of smallpox after she did the short, short man. 2. She had a bad case of smallpox after she did the short, short man.
by chickiechickie September 13, 2007

The Urban Dictionary Mug

Lotsa space for your liquids.

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The Urban Dictionary Mug

Lotsa space for your liquids.

Buy the mug

The Urban Dictionary Mug

Your favorite word on a white mug.

Create a mug

The Urban Dictionary Mug

One side has the word, one side has the definition. Microwave and dishwasher safe. Lotsa space for your liquids.

Buy the mug

The Urban Dictionary T-Shirt

Soft and offensive. Just like you.

Buy the t-shirt

The Urban Dictionary T-Shirt

Smooth, soft, slim fit American Apparel shirt. Custom printed. 100% fine jersey cotton, except for heather grey (90% cotton).

Buy the t-shirt