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1.
to get beat up.

to get slaped.
man the homie got smacked up

they smacked him up good.
by Delfino [YnR] January 18, 2008
 
2.
when one looks busted in the facial area
"honey, how do i look with this new makeup on?"
"you look smacked-up, ho."
by Angelica August 20, 2003
 
3.
British slang term for drugged/doped up. Term comes from the slang term for heroin that known as smack.
"She looked so smacked up."
by lovepollution April 04, 2010