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1.
What one often does after a breakup -- usu. the end of a longterm, monogamous relationship -- which involves promiscuous sex and/or sex play with a variety of partners. Sometimes accompanied by malicious intent.
"It's only been two weeks since I dumped my boyfriend and I've already slutted it up with two other people!"
by Megan Redhead October 26, 2001
 
2.
V. the act of being promiscuous.
"So how you been?"

"still slutting it up. You know how we do...."
by Annonnimous (sp) February 12, 2009