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The condition at which the effects of alcohol on the brain are exaggerated due to consumption at any altitude higher than 1,000 ft. (ie. skyrise bars, airplanes, mountaintops, etc.)
Jason: Whoa, what happened to you guys?!

Ashley: We went to the Sky Lounge so Darren could have a great view of the city. However, after one martini he got sky-drunk and I had to bring him home.
by darrenxix January 18, 2013