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1.
sko
abreviation for "let's go", usually accompanied by a head nod in the direction of the door.
"S-K-O, what's that spell"
"what?"
"'sko!"
by griffin October 20, 2004
 
2.
Acronym for "some kind of Spanish." Pronounced "skahz."

Adjective used to describe hot looking, olive complected women with flashing dark eyes and voluptuous figures who might also be totally Italian.

Origin:
Peterotica, a collection of adult novels written by Peter Griffin, protagonist of the American television show "Family Guy."

Excerpt from Peterotica: I'm Betty White reading "The Hot Chick Who Was Italian or Maybe Some Kind of Spanish" by Peter Griffin. Chapter one, Oh god, you should have seen this one hot chick. She was totally Italian...or maybe some kind of Spanish.
Steve1: Did you see that woman checking me out?
Steve2: Yeah man, she was totally hot.
Steve1: I think she's Italian...or...maybe...
Steve2: SKOS!
Steve1: Yeah, skos! Totally SKOS!!!
by Chud Fembot July 24, 2007
 
3.
'sko is an abbreviation for let's go
"this is shit"
"ok 'sko bro"
"sko"
by sko bro August 06, 2006
 
4.
sko
A social slur for any female. Mainly applies to those of the slutty nature. Someones considered a merging of the words skanky whore or skanky ho.
Did you know that girl you were conversing with the other night is a dirty sko.
by dkn May 27, 2003
 
5.
SKO
SKO- noun, tripple threat.
Slut, skank, and ho all in one. The dirtiest of deviants and the grimiest of whores.
I once curb stomped a sko, she liked it.
by Cia3390 May 19, 2011
 
6.
Sko
a Skank and a ho combined.
Shut the hell you fucking sko!
by Roy15 March 30, 2006
 
7.
sko
Combining the two words "skank" and hoe". Used when describing females who are "slutty" and "nasty" or if you just aren't fond of them at all and they deserve to be called something rude.
Ohmygod look over there, that girl is a total sko! I heard she did like 600 guys and has a boyfriend but cheats on him ALL THE TIME.
by ohmygoshitsme June 14, 2009