Pretty much whatever you want it to mean, it's an on going joke to trick people into believing that their is something on their shoe, face, clothes, or any other place on the body.
Good lord! There's skizzle all over your face.
by Skizzlemasta October 07, 2003

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Top Definition
Friend, Partner, or Accomplice
You my skizzle, dawg. I'm just hangin' wit my skizzles.
by Gump October 21, 2004

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Plural form of "skizzle". Both forms already defined under "skizzle".

Friend, Partner, or Accomplice
From "skizzle":

You my skizzle, dawg. I'm just hangin' wit my skizzles.
by SKIZZLE! August 02, 2005

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Mad skills; or as referring to having great talents.
That girl has mad SKIZZLES in math.
He has mad SKIZZLES in acing tests.
by Cheyley December 23, 2006

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a slut who has no shame and does sexual things in public
omg look at that skizzle! she has no self respect
by yoshigirlyeah March 12, 2012

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A skizzle is when a person or pet takes a shit then proceeds to drag their ass on the floor leaving behind a streak of feces.
Skizzle is basically slang for "skidmark".
"Look! That ugly fuck just made a skizzle on the ground over there!"
via giphy
by Word$mith101 September 12, 2016

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mad skills on video games
man you got some skizzles on san andreas
by masta s July 12, 2005

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People who are from liverpool (scousers)
Skizzles on Tizzle (Scousers on Tour)
Look at that skizzle, isn't he propa mad!
by Jay_90_08 June 19, 2008

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