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1.
a hy-bread word for "skank", used for the skankiest of skanks
"Get out of my face you dirty skizank"
by Mike Lynch December 23, 2002
 
2.
Commonly used as an insult, the term Skiz-Ank is a translated form of the word Skank into reverse ebonics. A Skiz-Ank is a generally gross/nasty-ass bitch that can be found in the slums of any respectable ghetto. Skiz-Anks are easily spotted by their crazy-ass afro-ish hair weave, and their unwashed/stained apparel. Also Skiz-Anks should be avoided at all cost, due to their violent tendencies.
"yo, nigga check out that Skiz-Ank with the rat in her hair"

"Yeah bro I wouldn't touch that dirty Skiz-Ank with any of my numberous extremities"
by Jake Andrews February 22, 2005
 
3.
A pretty girl who has skanky qualities but everyone loves. Commonly a Rachel or a Lucy.
That skizank has nice shoes today.
by Rprimm93 December 09, 2010