1. Any ailment, sexually-transmitted or otherwise, that one contracts from hooking up with a skeeze.
2. A general classification for any unknown or unidentifiable STD.
1. Dude, i'm dying. I have no idea what's wrong with me.
Um, you probably got skeeze disease from that chick you were making out with at the bar last night.
2. I've got something weird going on down there. I think I may have caught skeeze disease. I'm headed to the free clinic this afternoon to get it checked out.