Genereally means bastard, but not in the literal term. Just an annoying person who you don't like or who has done something stupidly irritating. Most comonly known from Mean Girls.
"Oh my god, you're such a skeese"
by Ill Hubs January 17, 2010
a hoe; a person that wants only relations and not a relationship
Many hoes and whores can be considered skeeses
by alypd January 14, 2007