Top Definition
Large-sized, unattractive woman who wears elaborate make-up and dress like they're all that and a bag of chips.

Most often seen in ghetto situations and/or on public transit vehicles like buses and subway cars.

Often found in the company of women who dress like guys because they think it's cool.
Why is that skankopotamus wearing a pink thong on her fat ass? Who's going to hit that shit? ACK!
by Stormcastle June 21, 2011
A nasty skank who needs absolute attention, and tries to fuck everyone.
That girl Brandi is such a disgusting skankopotamus, she hates me because I won't fuck her nasty ass.
by Nutsinabag March 10, 2016

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