Top definition
a person that is very close to you and you love like a sister. you tell them everything and are best friends. you are almost always with each other. sista frans are BEYOND just friends
Shea: is that girl Katie your friend?
Carly: She's not only my friend, she's my sista fran

or
Katie: hey sista fran, what's up?
Carly: nothing much, wanna hang out. go shopping or something?
by runnergirl365 February 05, 2011
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2
When you get excited you can refer to the person you're talking to as Sistafran.
"I am a communist."
"OMG SISTAFRAN! NO WAY, ME TOO!"
by Mike I May 06, 2005
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