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1.
First made popular by Kat Williams, a simple bitch is someone, male or female, who is a wimp and needs other peoples approval/acknowledgment for everything they do.

Basically they are so annoying and needy you just yell... "Shut up, SIMPLE-BITCH!"

Lisa- "You fucked up my self esteem"
Mike-" It's the steem about your motherfuckin' SELF, How the fuck did i fuck up how YOU feel about YOU; Simple-Bitch!"

Plural

Bunch of nerds outside of a frat party

Nerds- "Hey come on dude, let us in, we know people!
Big Frat Guy-"Get out of here nerds, go play some role playing game"
Nerds-"Ok fine, we will, we got our own Bud Light with Lime 18 pack back at our apartment and i haven't played WoW in 18 hours"
Big Frat Guy- "Simple-Bitches!"


by Bolt M.D. February 14, 2009
 
2.
THIS IS A BITCH THAT DOES NOTHING BUT DUMB STUPID SHIT.. HAS TO SOMTHING LIKE A BLOND, KEEPS DOING THE SAME OLD DUMB SHIT.. JUST SIMPLE
GURL I TLD U NOT TO MESS WITH THAT GUY HE DONT WANT YOU AN NOW HE PLAYED YOU.. YOU JUST A SIMPLE BITCH TO NOT LISTEN
by BEAUTIFUL B December 30, 2008
 
3.
A Simple Bitch is the female version of a Simple Dick.

Simple Bitch can be applied to men as well. Calling a man a Simple Bitch is a more degrading term than merely saying Simple Dick.
Carmine: "You know, you've really done it this time! Stop being such a simple bitch and grow the fuck up already!"

Lucian: "Its good to finally know what you really think of me."
by Ms. Lacuna August 09, 2009