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There is no worded, or formal, definition of Sikeston, MO, really.
It is only defined by use of examples.
Also, certain things can only be described accurately by using this term.
Therefore, the definition of Sikeston, MO is the phrase itself.
"Man that girl is ugly."
"Yeah she is sikeston, MO fo sho."
"I heard that she is really shady."
"Yeah, that's sikeston."
by Todd July 08, 2003