2. The phrase can also be used to genuinely show sympathy for things, similar to the usage of 'That sucks.' This usage usually is preceded by 'well.'
Person B: Well whoop-de-doo, sice your life.
Person A: Hey. Don't be mean. :(
Person A: Where's Tina?
Person B: She had to babysit today.
Person A: Oh...well sice her life. :(
Person B: I know, right?