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1.
v. To inject drugs intravenously.

See also bang,boot up
Watching my friends shoot up always transfixes me, although I'd never do it myself.
by Holly-Day February 02, 2004
 
2.
Other than the intravenous drug use meaning, it also means to increase very suddenly and rapidly.
So boss, as this graph clearly demonstrates...if we allow our workers to shoot up on the job, our employee satisfaction level will shoot up 34%!
by Nick D February 02, 2006
 
3.
to smoke a cigarette
"Hey, let's go outside and shoot up"
by Jonathan Simons April 28, 2008