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5.
General statement of amazement or disgust.
"Holy shitballs, Jim! Did you see her ass?"

or;

"Holy shitballs, those are some nasty-ass pubes."
by Justin Herbert July 18, 2007
 
1.
explitive; explaining great frustration or fright
As Dan was smoking a fat marijuana joint he quickly saw his father enter his house and exclaimed "oh, shitballs".
by cliff December 06, 2002
 
2.
An exlamation one cries out when they REALLY screw up.
On the way back home from the grocery store, Betty looked in the backseat of her car and realized she had left her four-year-old son in the carraige... way back at the store.

"Oh, shitballs!" She cried.
by Lisa V June 03, 2005
 
3.
Slang term used in the incident of getting fucked, to say when one is going to get in trouble.
"Oh shitballs, I didn't know that was your sandwich."
by Hoolio, King of Nothing July 30, 2003
 
4.
When a guy wipes from back to front after taking a crap and gets shit on his balls.
OH CRAP!!! I wiped the wrong way. Now I have Shit Balls.
by Ferret79 June 05, 2007
 
6.
A low-life loser; degenerate.
What a shitball! He killed his family!
by staccato brainstem February 12, 2005
 
7.
An exclamation of anger, frustration, tiredness, or sometimes even joy. Shit Balls can be taken to mean one of two things:

1) Balls or testicles that are coated or encrusted in shit.

2) Small amounts of feces clumped into balls
Larry: Sorry man, I can't give you a ride today.

Ricky: Aw, Shit Balls! Now I have to walk!

Larry: Suck one.
by Larry Finster December 26, 2009