Top Definition
The act of taking illegal drugs or alcohol in attempt to alleviate anxiety, stress, or certain mental disorders (ie. schizophrenia & bipolar).
I'll tell you what, this job has me so stressed out that I am going home to self medicate with some hard booze.
by Almighty_AL April 19, 2005
1 more definition
v. To alleviate one's self of physical or mental pain through alternative forms such as recreational drugs or alcohol
Tom: Your back is pretty bad man, go see a doctor.
Jim: Nah brah, I'll just self-medicate with a 5th of vodka
by Chris24O April 08, 2010

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