1. To engage in an MSN Messenger conversation with a greeting, and then never typing another word.
Hey man what's up
Nothing new Samer, what's up with you?
You there man?
2. Also can be used to agree with somebody.
Matt: Hey, look at those two, they are like twins.
Eric: They're samers.
Example Definition 2:
Paul: I am hungry as shit man, I want to get some food.