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1.
Doing something that is just considered not right. Or something happening thats not right.
Bob lost the smoke money.. thats sacrilege
by mixer-meso February 25, 2006
 
2.
an exclamation accompanied by shaking your fist at someone, usually over some horrible injustice or blasphemy.
"No hot dog buns? Sacrilege!!"
by kmuff July 30, 2004