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when someone takes charge of a situation and or take the lead in a activity.

or when one plays by their own rules.
Jack is winning at poker "Jacks running the show tonight"

Everyone disagrees with Marshall's decisions, "Shut up i am running the show now"
by tomito March 03, 2009
(adverb) How devout members of Alcoholics Anonymous (AA) describe the attitude and actions of an alcoholic who is not following the principles of the Twelve-Step program and the Big Book.

They believe that this person does not "know how to take direction."
"Sandy still thinks she can drink only on weekends and stop during the week. She continues to run the show."
by Twelve-Step slang November 20, 2004