Top Definition
This syndrome could happen at any time but can be intensified by the consumption of alcohol. This is what happens when one cannot stop bragging on themself and all of their best qualities. When alcohol is involved, they may make the same statements repeatedly and loudly as a means of inforcing the validity of the statement and/or tell stories that magnify their greatness.
Hey boss, I am really glad to see you out tonight. I wanted to talk to you about the recent promotion I put in for. I know you gave the position to Mike but I think there are a few things you overlooked....

Two friends watching interaction painfully in the distance;
Friend 1: Oh man, Sam has a bad case of runaway ego syndrome tonight. Should we save him?
Friend 2: No man, let's let it play out a little bit first.
by Kaelli June 15, 2010

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