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1.
a girl who loves it to check out the whole crowd of boys in her class or any other community for having sex
she´s got a real runaround-sue by chamging the boy friend three times a week!
by steppenwolf November 19, 2006
 
2.
A Female that gets around. A slut, tramp, whore, etc... Originating from the classic song "Run around Sue" by singer Dion in 1961, the song clearly explains a lose woman that "took my heart and ran around, with every man in down". It is a more classy way to call a girl a Slut.
I don't think you want to take that girl serious she's a Run around sue.

That Run Around Sue has smashed half the city.
by Pimpshitnigga April 22, 2011