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2.
A game that requires everyone playing to get naked. One participant, in a separate room, puts roofies in every drink except for one. Then a different participant comes into the room and mixes up all the drinks and brings them into the room with all the other participants. Everyone drinks a cup and the one person who doesn't get roofied gets to do whatever they what to the rest of the helpless, passed out participants.
We played Roofie Roulette last night, and my ass is killing me
by John Walter D January 26, 2011
 
1.
a joyous game in which 20+ shot glasses are filled with hard alcohol and placed on a lazy Susan or spinning table,in which 4 roofies are dropped,and each person playing takes shots at random to see who gets one.its a good idea to make sure most of your friends have cameras on them.
its fun for the whole family!
muttered in a sobbing voice "got im never playing roofie roulette again,i need to go to the doctor...."
by jesse lindsay January 03, 2008
 
3.
a game played between 5 or more friends in which each participant begins with a drink and a third party discreetly roofies one glass. Blindly, each person selects a beverage and imbibes. Conversation and ambiance continue as usual until one unfortunate "winner" begins to feel the effect of the roofie and blacks out. Hilarious games and pranks can be played, but the winner must be put into bed... eventually. Optional: Leave the door open and alert all additional friends (of the opposite sex) of the situation. In the end, any and everyone has a good night!
Friend: "Hey what happened to me last night? I swore I only had one drink and then I blacked out. And yet, I feel strangely satisfied..."
Other friend: "Looks like you were the lucky winner of roofie roulette!"
by Ms. Hosy McLiverdamage December 16, 2007