Top Definition
Restless Leg Syndrome of the Third Leg. When a man can not keep his penis in his pants. This can either imply he is messing around or that he is very sexually active in general.
Greg: Did you go out with your girlfriend last night?
Andy: No, I met up with some other chick at the club, then banged her.
Greg: Dude, you have a serious case of rls3!
by mmecochineal June 17, 2007

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