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1.
having a baby at age 40 or older. Babies born to women who are 40 or older have a much higher risk of being born with developmental or cognitive disabilities, like Down's syndrome, mental retardation, and autism. Thus, anyone who has a baby over 40 is gambling with their baby's health -- hence, "roulette."
"Kelly Preston is having a baby at age 47? She's playing retard roulette with that pregnancy."

Sarah Palin's son, Trig, has Down's syndrome and was born when Sarah was 44.
by Liz Lime December 23, 2010