Top definition
Something that is irritating or annoying, particularly to an overweight female. To rankle- to annoy. Cankles- see urban dictionary definition.

Can be said in jest, referring to yourself as a fat woman when you are not.
I can't believe Todd didn't pick up the tab at Golden Corral, that really rankles my cankles!
by Smittytricks December 28, 2011
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