It's simply the phrase 'give up' except ghetto people like to replace 'g' with 'q' like it will add any more significance to the sentence it's being used in. It really doesn't though. It just makes you look stupid. So if you wanna be ghetto, go ahead use the damn q. It won't change anything.
My ghetto boyfriend hasn't called me in like 5 hours. I qive up yo.