(Portuguese) It means almost the same as puta, although it is considered to be slightly less insulting. It only applies to women; the portuguese equivalent of man-whore, "mulherengo", is not considered an insult.
Basically, a "putefia" is a woman of loose morals, a contemptible slut in the eyes of other women and/or men.
Uma putéfia, é o que ela é! - exclamou a Joana. / A slut, that's what she is! - cried Joana
Já cá faltava a putéfia! - disse o Tiago / Mind your own business, biatch! - said Tiago